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Representative chemical probes of Kme readers with unique binding modes and mechanisms
| Kme Reader | Chemical Probe |
||
|---|---|---|---|
| Name | Modality | Structure | |
| NSD3 (PWWP) | BI-9321 | Small Molecule Cavity Binder |
|
| SPIN1 (Tudor) | VinSpinIn | Bidentate Small Molecule |
|
| CBX7 (CBX) | UNC3866 | Peptidic Surface-Groove Binder |
|
| EED (WD40) | MAK683 | Allosteric Modulator |
|
| EED (WD40) | UNC6852 | PROTAC Degrader |
|
