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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: J Invest Dermatol. 2021 Mar 23;141(9):2208–2218.e14. doi: 10.1016/j.jid.2021.02.749

Figure 1. PN lesional skin is characterized histologically by marked inflammatory cell infiltrate, robust architectural changes, and greater immunofluorescence signal intensity of IL1A and SERPINB4.

Figure 1.

a, H&E staining of lesional PN, non-lesional PN, and matched healthy control skin tissue biopsies from African American females. b, Average epidermal thickness as measured at the thickest suprapapillary epidermal plate. c, Blinded dermatopathologist assessed degree of inflammation (0 = no, 3 = severe). d, Blinded dermatopathologist assessed presence (1) or absence (0) of specific inflammatory cell infiltrate across different skin samples with the average value shown. e, Immunofluorescence staining (IF) of DAPI, IL1A, and SERPINB4 in lesional PN and matched healthy skin from African American females with overlapping areas highlighted in gold. *p-value < .05, ** p-value < .01, and *** p-value < .001. PML, polymorphonuclear leukocyte; L, lymphocytes; N, neutrophils; E, eosinophils; M/H, macrophages / histiocytes; MC, mast cells; PC, plasma cells. 5x scale bar = 200um; 10x scale bar = 100um; 20x scale bar = 50um; 40x scale bar = 20um; IF scale bar = 200um.