Figure 1: Treatment effect on change in urine protein at 6 months, on 3-year total GFR slope, and on chronic slope.
Treatment effects on urine protein are expressed as geometric mean ratios and were estimated by performing analyses of covariance within each study. Treatment effects on slope are difference in glomerular filtration rate between treatment and control arm and are expressed as ml/min/1.73m2/year and were estimated using a shared parameter mixed effects model. The circles represent the estimated treatment effects and the horizontal line the 95% confidence intervals. UP, urine protein measured in gram/day.