Table 2.

Association of Factor Scores with Continuous eGFR Change^†

	Unadjusted β (95% CI)	Model 1* β (95% CI)	Model 2** β (95% CI)
Tubule Injury/Repair (NGAL, IL-18, and YKL-40)	−0.44 (−0.59, −0.28)	−0.38 (−0.56, −0.21)	−0.06 (−0.24, 0.12)
Tubule Injury/Fibrosis (KIM-1 and MCP-1)	−0.41 (−0.57, −0.25)	−0.34 (−0.50, −0.18)	−0.16 (−0.33, 0.01)
Tubule Reabsorption (α1m, β2m)	−0.90 (−1.06, −0.74)	−0.71 (−0.87, −0.54)	−0.07 (−0.25, 0.12)
Tubule Reserve/Mineral Metabolism (UMOD, iPTH, iFGF23)	−0.94 (−1.09, −0.78)	−0.96 (−1.13, −0.80)	−0.58 (−0.76, −0.39)
Albumin-creatinine ratio	−1.74 (−1.89, −1.58)	−1.58 (−1.74, −1.42)	−1.53 (−1.69, −1.36)

^†Percentage changein eGFRper year

^*model 1: age, sex, race, randomization arm, SBP, DBP, number of antihypertensive meds, ACEi or ARB use, diuretic use, history of CVD or HF, current smoker, BMI, LDL, total cholesterol.

^**model 2: model 1 + baseline eGFR and UACR

Each factor is modeled per SD higher. ACR was log transformed and represents a SD higher on the log scale, to provide a reference for comparison of strengths of association.