Table 3.

Association of Factor Scores with Future Risk of Acute Kidney Injury

# AKI Events = 184	Unadjusted HR (95% CI)	Model 1* HR (95% CI)	Model 2** HR (95% CI)
Tubule Injury/Repair (NGAL, IL-18, and YKL-40)	1.19 (1.04, 1.36)	1.28 (1.11, 1.49)	1.18 (1.01, 1.37)
Tubule Injury/Fibrosis (KIM-1 and MCP-1)	1.33 (1.12, 1.58)	1.33 (1.11, 1.60)	1.23 (1.02, 1.48)
Tubule Reabsorption (α1m, β2m)	1.33 (1.15, 1.54)	1.29 (1.11, 1.50)	0.96 (0.81, 1.14)
Tubule Reserve / Mineral Metabolism (UMOD, iPTH, iFGF23)	1.59 (1.39, 1.82)	1.54 (1.33, 1.78)	1.19 (0.99, 1.42)
Albumin-creatinine ratio	1.58 (1.39, 1.80)	1.50 (1.31, 1.73)	1.30 (1.11,1.51)

^*model 1: age, sex, race, randomization arm, SBP, DBP, number of antihypertensive meds, ACEi or ARB use, diuretic use, history of CVD or HF, current smoker, BMI, LDL, total cholesterol.

^**model 2: model 1 + baseline eGFR and UACR

Each factor is modeled per SD higher. ACR was log transformed and represents a SD higher on the log scale.