. Author manuscript; available in PMC: 2022 Sep 10.

Published in final edited form as: J Pharm Biomed Anal. 2021 Jul 21;204:114274. doi: 10.1016/j.jpba.2021.114274

Table 3.

Matrix effect and recovery evaluation for JQ1 in mouse plasma and microdialysates (n=3).

Sample Matrix	Compound	Nominal Concentration (ng/mL)	Matrix Effect		Recovery
Sample Matrix	Compound	Nominal Concentration (ng/mL)	Mean calculated MF value	% R.S.D.	% Mean Recovery	% R.S.D.
Mouse Plasma CD1	JQ1	15	0.95	4.91	82.18	6.50
	JQ1	800	1.01	0.26	90.09	6.48
	ISTD	500	0.99	2.66	74.84	11.01
Mouse Plasma CD1 nude	JQ1	15	0.96	5.77	84.43	2.88
	JQ1	800	1.00	0.93	92.99	1.31
	ISTD	500	0.99	2.72	78.31	7.49
Microdialysate	JQ1	1.5	0.97	8.66	104.35	4.43
	JQ1	400	1.01	0.21	96.00	1.55
	ISTD	500	1.03	0.65	87.24	5.60

%RSD: relative standard deviation