Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
JQ1 pharmacokinetic parameter estimates.
| Parameter (Unit) | Definition | Estimate (RSE%) | IIV (RSE%) |
|---|---|---|---|
| Plasma model | |||
| CL (L/h/kg) | Central clearance | 4.3 (11) | 0.32 (25) |
| V (L/kg) | Volume of distribution | 7.0 (11) | 0.33 (24) |
| Extracellular fluid (ECF) model | |||
| CLin (L/h/kg) | Plasma to ECF influx clearance | 4.01·10−5 (6) | 0.11 (47) |
| CLef (L/h/kg) | ECF to plasma efflux clearance | 1.24·10−3 (1) | - |
RSE%: relative standard error; IIV: interindividual variability reported as standard deviation
