Table 1:
Baseline characteristics of physical crossmatch (N=71,839) and virtual crossmatch (N=9,632) cohorts.
| Crossmatch Type | ||
|---|---|---|
| Physical XM | Virtual XM | |
| (N = 71,839) | (N = 9,632) | |
| Donor age (years), Median (IQR) | 39 [26, 51] | 40 [26, 51] |
| Female donor | 28,081 (39%) | 3,660 (38%) |
| Black Donor | 10,527 (15%) | 1,299 (13%) |
| Donor serum creatinine (mg/dL), Median (IQR) | 0.9 [0.7, 1.3] | 1.0 [0.7, 1.5] |
| KDPI (%), Median (IQR) | 38 [17, 61] | 41 [20, 63] |
| KDPI > 85 | 3,938 (5%) | 620 (6%) |
| DCD donor | 13,824 (19%) | 1,664 (17%) |
| Machine perfusion | 28,584 (40%) | 2,208 (23%) |
| Donor kidney biopsy | 34,901 (49%) | 4,393 (46%) |
| Import kidney | 18,769 (26%) | 3,436 (36%) |
| Transplant center volume (DDKT/year), Median (IQR) | 82 [52, 134] | 131 [74, 176] |
| Transplant centers per OPO, Median (IQR) | 4 [2, 9] | 4 [4,10] |
| Recipient age (years), Median (IQR) | 55 [44, 63] | 56 [46, 64] |
| Female recipient | 28,762 (40%) | 3,612 (38%) |
| Recipient race | ||
| White | 41,223 (57%) | 5,907 (61%) |
| Black | 24,549 (34%) | 2,427 (25%) |
| Asian | 4,581 (6%) | 1,118 (12%) |
| Other | 1,486 (2%) | 180 (2%) |
| Recipient BMI (kg/m2), Median (IQR) # | 27.9 [24.2, 32.1] | 27.2 [23.7, 31.2] |
| ESRD cause | ||
| Hypertension | 18,030 (25%) | 2,026 (21%) |
| Glomerular disease | 15,542 (22%) | 1,737 (18%) |
| Diabetes Mellitus | 19,679 (28%) | 2,757 (29%) |
| PKD | 5,597 (8%) | 579 (6%) |
| Other | 12,699 (18%) | 2,503 (26%) |
| Pre-transplant dialysis | 63,967 (89%) | 8,214 (86%) |
| Dialysis duration (months), Median (IQR) | 49.9 [27.2, 76.6] | 50.9 [20.9, 85.7] |
| Time on waitlist (months), Median (IQR) | 24.8 [7.7, 46.5] | 18.9 [3.4, 48.6] |
| Prior kidney transplantation | 9,834 (14%) | 877 (9%) |
| CPRA | ||
| <10% | 45,298 (63%) | 6,848 (71%) |
| 10% – 80% | 13,457 (19%) | 1,513 (16%) |
| 81% – 98% | 7,495 (10%) | 681 (7%) |
| 99% −100% | 5,579 (8%) | 588 (6%) |
| Zero HLA ABDR mismatch # | 4,377 (6%) | 564 (6%) |
| Induction therapy | ||
| None | 9,431 (13%) | 1,427 (15%) |
| Thymoglobulin | 41,521 (58%) | 4,690 (49%) |
| lnterleukin-2 Blocker | 10,222 (14%) | 2,726 (28%) |
| Alemtuzumab | 10,665 (15%) | 789 (8%) |
BMI: Body mass index; CPRA: Calculated panel reactive antibody; DCD: Donation after cardiac death; DDKT: Deceased donor kidney transplantation; ESRD: End stage renal disease; HLA: Human leukocyte antigen; IQR: Interquartile range; KDPI: Kidney donor profile index; OPO: Organ procurement organization; PKD: Polycystic kidney disease; XM: crossmatch
#
Missing data was <0.5% for all variables except for recipient BMI (0.84% missing) and 0 HLA ABDR mismatch (0.62% missing)