. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: Cardiovasc Intervent Radiol. 2021 May 21;44(9):1439–1447. doi: 10.1007/s00270-021-02853-x

Table 1.

Biopsy target and tissue results.

Biopsy #	CT targeted Location	Targeted tissue based on cytology or histopathology	POC Reviewers score (mean± SD)	Cytology touch preparation	Pathology confirmed diagnosis
1	LIRADS 5 / Hypodense part	HCC	2.9 ± 0.2	Atypical hepatocytes, favor for HCC	Majority of the section has marked micro to normo-vesicular hepatocellular lipidosis. Multifocal areas of moderate lymphocytic infiltrates are observed. A small focus of slightly enlarged hepatocytes double rowed with dilated sinusoids is observed (suspect adenoma)
2	LIRADS 5 / Hypodense part	HCC	2.4 ± 0.5	Atypical hepatocytes, favor for HCC	The majority of cells have moderate to marked vesiculation, have mild cell size and nuclear size variation, and a few rare large neoplastic cells are observed (HCC).
3	Left lateral lobe	Normal	0 ± 0	Mostly blood and benign-appearing hepatocytes	No tissue present
4	Left lateral lobe	Normal	0 ± 0	Mostly blood and benign-appearing hepatocytes	A small piece of only hemorrhage and necrosis and a section of liver with moderate to marked portal lymphocytic infiltrates, biliary hyperplasia and foci of vacuolated cells adjacent to portal areas are observed (chronic hepatitis).
5	Left lateral lobe	Normal	-	Atypical hepatocytes, favor for HCC	Within normal liver limits.
6	LIRADS 5 / Hyperdense part	HCC	2.1 ± 0.2	Atypical hepatocytes, favor for HCC	Mixture of cells with moderate vesiculation and trabeculae of amphophilic neoplastic cells is observed/
7 ^*	LIRADS 5 / Cranial part; normal iver, quadrate obe	HCC	2.2 ± 0.3	Atypical hepatocytes, favor for HCC	Both sections have areas of normal hepatocytes, mildly vesiculated hepatocytes, trabecular hepatocytes and multiple bizarre giant cells. A few foci of moderate to marked lymphocytic infiltrates are observed (HCC).
7.1 ^*	LIRADS 5 / Cranial part; normal iver, quadrate obe	HCC	2.0 ± 0	Atypical hepatocytes, favor for HCC
8	LIRADS 5 / Hypodense part	Normal/Non-diagnostic	0.2 ± 0.4	Non-diagnostic, mostly blood	No tissue present.
9	LIRADS 5 / Hypodense part	Normal/Non-diagnostic	0.6 ± 0.5	Non-diagnostic, mostly blood	No tissue present.
10	Right lateral lobe posterior	Normal/Non-diagnostic	0.5 ± 0.5	Non-diagnostic, mostly blood	Skeletal muscle and collagen bundles only - no liver present.

For biopsy 7, the tissue was divided into two parts after cytology touch preparation and interpretation. The mean± SD for each core represents the average of the POC scores for the five independent reviewers.