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. 2021 Aug 14;27(30):5060–5075. doi: 10.3748/wjg.v27.i30.5060

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Brain-derived neurotrophic factor expression in lumbar-sacral spinal cord is regulated by estrogen. A: Plasma estrogen levels in cycling females that received a bolus estradiol (E2) infusion on day 1; B: Lumbar-sacral spinal cord brain-derived neurotrophic factor (BDNF) mRNA following bolus estrogen infusion; C: Lumbar-sacral spinal cord BDNF protein following bolus estrogen infusion. (n = 8 rats in each group, two-way ANOVA, ^aP < 0.05 vs vehicle group).