Table 1.
Electrophysiological characteristics of colon related DRG neuron
|
Classification
|
Ctr., n = 36
|
CAS, n = 34
|
CPS, n = 29
|
CAS + CPS, n = 45
|
| Spontaneous spike number | 7.4 ± 4.0 | 16.9 ± 6.6 | 11.7 ± 4.8 | 44.8 ± 14.6c |
| Membrane capacitance (pF) | 72.1 ± 4.9 | 95.4 ± 5.8 | 85.1 ± 6.2 | 93.8 ± 8.9a |
| Action potential threshold (mV) | -27.1 ± 2.5 | -29.2 ± 1.8 | -34.6 ± 1.6 | -38.6 ± 1.4c |
| Resting membrane potential (mV) | -60.1 ± 1.7 | -50.1 ± 1.3 | -53.8 ± 1.5 | -56.4 ± 1.3 |
| Cell diameter (μm) | 32 ± 0.9 | 29 ± 0.6 | 31 ± 0.8 | 31 ± 0.6 |
| Time constant (μm) | 545.5 ± 51.1 | 737.7 ± 70.4 | 595.9 ± 54.1 | 535.3 ± 42.5 |
| Action potential amplitude (mV) | 79.0 ± 4.7 | 80.2 ± 3.9 | 77.4 ± 4.2 | 85.6 ± 3.7 |
| Duration (ms) | 8.38 ± 0.97 | 11.2 ± 0.95 | 12.3 ± 1.83 | 8.89 ± 0.60 |
Values means ± standard error.
a
P < 0.05;
c
P < 0.001 vs control group. CAS: Chronic adult stress; CPS: Chronic prenatal stress.