Table 2.
Electrophysiological characteristics of colon related DRG neuron after Letrozole treatment
|
Classification
|
Veh. + CAS + CPS, n = 60
|
Let + CAS + CPS, n = 27
|
| Spontaneous spike number | 34.6 ± 11.3 | 8.04 ± 4.62c |
| Membrane capacitance (pF) | 86.8 ± 7.1 | 83.7 ± 6.7 |
| Action potential threshold (mV) | -34.6 ± 1.6 | -27.6 ± 2.1a |
| Resting membrane potential (mV) | -54.9 ± 1.3 | -54.6 ± 2.2 |
| Cell diameter (μm) | 31 ± 0.5 | 27 ± 1.6 |
| Time constant (um) | 502.7 ± 34.5 | 454.0 ± 36.6 |
| Action potential amplitude (mV) | 90.9 ± 3.7 | 89.8 ± 7.2 |
| Duration (ms) | 8.67 ± 0.63 | 10.70 ± 2.22 |
Values are means ± standard error.
a
P < 0.05;
c
P < 0.001 vs control group. CAS: Chronic adult stress; CPS: Chronic prenatal stress.