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. 2021 Aug 21;27(31):5259–5271. doi: 10.3748/wjg.v27.i31.5259

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Density and spatial distribution of macrophages in gastric carcinoma of different histological types. Immunohistochemistry for CD68. A and B: Intestinal type gastric carcinoma (GC) of inflamed tumor immune microenvironment (TIME) (A) with high count of CD68+ cells forming dense meshwork (B) inside the tumor. (A: × 100, B: × 200); C: High number of intratumor CD68+ cells of diffuse type GC of ID TIME, × 200; D: Prevalence of CD68+ cells in peritumor stroma of mucinous GC of IE TIME, × 200.