Table 2.
Immune cells number in gastric carcinoma of different histological types and tumor immune microenvironment
| Characteristics |
CD8+ cells
|
CD68+ cells
|
CD163+ cells
|
|||
|
TC
|
TS
|
TC
|
TS
|
TC
|
TS
|
|
| Histological type | ||||||
| Intestinal | 214 ± 44.9 | 202 ± 14.7 | 303 ± 21.7 | 244 ± 12.4 | 173 ± 17.3 | 170 ± 9.67 |
| 124-305 | 173-232 | 259-347 | 219-269 | 138-208 | 151-190 | |
| Diffuse | 49.5 ± 6.63 | 66.0 ± 6.03 | 339 ± 23.6 | 225 ± 23.8 | 51.7 ± 8.60 | 55.5 ± 8.94 |
| 36.0-63.1 | 43.6-98.3 | 291-388 | 176-274 | 34.1-69.4 | 37.2-73.9 | |
| Mucinous | 7.53 ± 2.50 | 52.5 ± 37.5 | 101 ± 59.0 | 219 ± 16.2 | 12.5 ± 11.8 | 62.5 ± 12.5 |
| 2.26-34.3 | 23.9-82.9 | 64-125 | 126-264 | 6.32-78.2 | 36-121 | |
| P = 0.045 | P = 0.059 | P = 0.071 | P = 0.471 | P = 0.032 | P = 0.011 | |
| TIME type | ||||||
| ID | 43.7 ± 4.05 | 43.2 ± 5.93 | 367.5 ± 36.9 | 213.1 ± 35.9 | 72.5 ± 18.3 | 48.7 ± 10.5 |
| 35.1-52.3 | 30.6-55.7 | 288-446 | 135-290 | 33.2-111 | 26.2-71.2 | |
| IE | 19.4 ± 3.43 | 112 ± 15.2 | 157.3 ± 29.6 | 266.6 ± 25.8 | 55.5 ± 13.6 | 119.5 ± 16.3 |
| 12.2-26.7 | 80.1-144 | 94.5-220 | 211-321 | 26.5-84.4 | 84.9-154.1 | |
| Inflamed | 229 ± 44.9 | 190 ± 16.5 | 352.8 ± 15.6 | 232.6 ± 13.7 | 165.6 ± 18.2 | 151.3 ± 12.1 |
| 138-319 | 156-223 | 321-384 | 204-260 | 128-202 | 126-175 | |
| P = 0.042 | P = 0.004 | P = 0.674 | P = 0.060 | P = 0.024 | P = 0.011 | |
| Status PD-L1 expression | ||||||
| Positive | 341 ± 72.3 | 204 ± 52.7 | 430 ± 27.7 | 200 ± 8.19 | 231 ± 54.3 | 135 ± 29.5 |
| 66.3-488 | 58.4-350 | 341-518 | 174-226 | 58.4-404 | 41.3-229 | |
| Negative | 49.0 ± 13.1 | 116 ± 20.7 | 261 ± 41.4 | 279 ± 37.9 | 96.3 ± 28.0 | 131 ± 28.2 |
| 20.1-77.9 | 72.0-159 | 169-352 | 195-362 | 34.6-157 | 69.5-193 | |
| P = 0.010 | P = 0.075 | P = 0.252 | P = 0.715 | P = 0.032 | P = 0.260 | |
TC: Tumor clusters; TS: Peritumor stroma; TIME: Tumor immune microenvironment; PD-L1: Programmed death-ligand 1; ID: Immune desert; IE: Immune-excluded.