Table 1.
Immunohistochemical biomarker expression levels in 22 GBM patients histopathologically confirmed.
| Prognostic Factor | Number of Patients n (%) | IDH-1-R132 |
HIF-1-α |
p53 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Negative n (%) | Positive n (%) | P-value n (%) | Positive n (%) | Negative n (%) | P-value n (%) | Positive n (%) | Negative n (%) | P-value n (%) | ||
|
Age 18–50 Years >50 Years |
6 (27) 16 (73) |
2 (33) 10 (63) |
4 (67) 6 (37) |
0.229 | 3 (50) 7 (44) |
3 (50) 9 (56) |
0.583 | 2 (40) 10 (67) |
3 (60) 5 (33) |
0.363 |
|
Sex Male Female |
14 (64) 8 (36) |
3 (38) 9 (64) |
5 (62) 5 (36) |
0.221 | 8 (57) 2 (25) |
6 (43) 6 (75) |
0.165 | 5 (62) 7 (58) |
3 (38) 5 (42) |
0.551 |
|
Karnofsky Performance status >70 ≤70 |
12 (55) 10 (45) |
7 (88) 9 (64) |
1 (12) 5 (36) |
0.026* | 5 (63) 5 (36) |
3 (37) 9 (64) |
0.546 | 5 (71) 7 (54) |
2 (29) 6 (46) |
0.663 |
|
Extent of resection Biopsy Sub-total Gross-total |
9 (41) 9 (41) 4 (18) |
6 (67) 5 (56) 1 (25) |
3 (33) 4 (44) 3 (75) |
0.257 | 4 (44) 4 (44) 2 (50) |
5 (56) 5 (56) 2 (50) |
0.699 | 6 (67) 3 (38) 3 (100) |
3 (33) 5 (62) 0 |
0.413 |
|
Corpus collosum infiltration Yes No |
18 (82) 4 (18) |
10 (56) 2 (50) |
8 (44) 2 (50) |
0.632 | 9 (50) 1 (25) |
9 (50) 3 (75) |
0.368 | 9 (56) 3 (75) |
7 (44) 1 (25) |
0.624 |
|
Edema Yes No |
16 (73) 6 (27) |
7 (44) 5 (83) |
9 (56) 1 (17) |
0.119 | 6 (38) 4 (66) |
10 (62) 2 (34) |
0.229 | 8 (53) 4 (80) |
7 (47) 1 (20) |
0.267 |
|
Mitotic activity Yes No |
22 (100) 0 |
12 (55) 0 |
10 (45) 0 |
10 (45) 0 |
12 (55) 0 |
12 (60) 0 |
8(40) 0 |
|||
|
Endothelial-capillary proliferation Yes No |
14 (64) 8 (36) |
8 (57) 4 (50) |
6 (43) 4 (50) |
0.460 | 7 (50) 3 (38) |
7 (50) 5 (62) |
0.454 | 8 (67) 4 (50) |
4 (33) 4 (50) |
0.449 |
|
Necrosis Yes No |
22 (100) 0 |
12 (55) 0 |
10 (45) 0 |
10 (45) 0 |
12 (55) 0 |
12 (60) | 8 (40) | |||
|
Cell Density Moderate High |
4 (18) 18 (82) |
2 (50) 10 (56) |
2 (50) 8 (44) |
0.632 | 2 (50) 8 (44) |
2 (50) 10 (56) |
0.632 | 2 (50) 10 (62) |
2 (50) 6 (38) |
0.574 |
*p < 0.05.
HIF-1α: Hypoxia inducible factor-1 alpha, IDH1: Isocitrate dehydrogenase 1, TP53: Tumour protein p53.