Duplicates removed	50
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	67
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	23
Cited efficacy/tolerability articles	21
Cited articles not efficacy/tolerability	24
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were budesonide/glycopyrronium/formoterol, Trixeo Aerosphere, BREZTRI AEROSPHERE, COPD. Records were limited to those in English language. Searches last updated 17 June 2021