Table 3.

Clinically important difference improvement from pre-operative to 3, 12 and 24 months points

Clinical outcome	Time point (months)	Mean difference	SD	95% CI	Significance level at each time pointa	Significance level over timeb
					p value	p value
KOOS-Pain	3	16.73	2.77	11.20–22.25	< 0.0001
	12	22.92	3.46	16.02–29.82	< 0.0001
	24	26.28	3.22	19.86–32.70	< 0.0001	0.002
KOOS-Symptoms	3	8.05	2.79	2.48–13.62	0.005
	12	17.58	2.95	11.70–23.46	< 0.0001
	24	18.3	2.81	12.70–23.90	< 0.0001	< 0.0001
KOOS-ADL	3	16.42	2.85	10.73–22.10	< 0.0001
	12	24.75	3.28	18.20–31.29	< 0.0001
	24	22.75	3.18	16.42–29.09	< 0.0001	< 0.0001
KOOS-Sport	3	9.47	4.1	1.28–17.66	0.024
	12	23.06	4.53	14.02–32.09	< 0.0001
	24	25.27	4.13	17.04–33.50	< 0.0001	0.002
KOOS-QoL	3	14.6	3.17	8.27–20.92	< 0.0001
	12	24.05	3.76	16.54–31.55	< 0.0001
	24	25.26	3.57	18.14–32.37	< 0.0001	< 0 .0001
VAS	3	26.31	3.22	19.89–32.73	< 0.0001
	12	27.12	4.29	18.57–35.67	< 0.0001
	24	30.22	3.95	22.34–38.11	< 0.0001	< 0.0001

^aOne sample paired t test

^bLinear mixed effects model