Table 3.
Genotypic frequencies of RAD51/G135C and ATM/P1054R genotypes in 114 gas station workers and 115 controls
| RAD51/G135C | ATM/P1054R | |||||
|---|---|---|---|---|---|---|
| GG | GC | CC | CC | GC | GG | |
| Group 1 | 59 (64.1%) | 29 (31.5%) | 4 (4.3%) | 70 (79.5%) | 18 (20.5%) | 0 (0.0%) |
| Group 2 | 9 (40.9%) | 10 (45.5%) | 3 (13.6%) | 19 (86.4%) | 2 (9.1%) | 1 (4.5%) |
| Total of workers N (%) | 68 (59.6%.) | 38 (33.3%) | 8 (7.0%) | 89 (80.9%) | 20 (18.2%) | 1 (0.9%) |
| Controls N (%) | 88 (72.2%) | 24 −(21.1%) | 2 (1.8%) | 92 (82.1%) | 20 (17.9%) | 0 (0.0%) |
| Total | 156 (68.4%) | 63 (27.6%) | 9 (3.9%) | 181 (81.5%) | 40 (18.0%) | 1 (0.4%) |
| P value | P value | |||||
| Hardy–Weinberg Equilibrium | 0.322 | 0.632 | ||||
| Total workers × controls | 0.011 | 0.930 | ||||
| Group 1 × Group 2 | 0.074 | 0.092 | ||||
| Polymorphisms assessment for CA detection | |||
|---|---|---|---|
| RAD51/G135C | ATM/P1054R | RAD51/G135C + ATM/P1054R | |
| Specificity (%) | 87 (76–94) | 79 (68–87) | 82 (75–88) |
| Sensitivity (%) | 28 (16–43) | 14 (16–43) | 24 (14–35) |
P value < 0.05 was considered significant
Descriptive measures: a (± b), a = average and b = standard deviation. (a−b), confidence interval sample, 95%