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. 2021 Aug 24;12:5107. doi: 10.1038/s41467-021-25433-6

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© The Author(s) 2021, corrected publication 2022

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Fig. 4 — These TRM combinations follow one of three criteria: (1) used in the wild-type Pumilio-1 PUF domain, indicated by * in the figure; (2) highly specific in both the random screen and targeted screen; or (3) best represent the pattern of the sequence logo in Fig. 3. The rows indicate each repeat position of the Pumilio-1 PUF domain, and the columns indicate the four RNA bases at the cognate positions. Red, TRM combinations used in the PUF domain designs; ---no highly base-specific TRM combination detected.