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. 2021 Aug 24;11:17087. doi: 10.1038/s41598-021-96651-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative amplification profiles of A. fumigatus wild type and environmental or clinical azole-resistant isolates with or without TR46 double or triple 46 bp promoter repeats in cyp51A gene by a newly developed LAMP primer sets. The dotted curve shows the amplification by control strain (IFM 63432). (A-i) DNA amplification profiles using 30 strains of A. fumigatus wild type. DNA amplification was not confirmed in all wild-type strains tested (30 strains). Among 30 wild-type strains, IFM 62918 strain was used as a negative control strain (no amplification). (A-ii) DNA amplification was confirmed by five TR₄₆² strains (IFM63432, BE1-2, BE1-4, BE3-5, BE3-6), which have double 46 bp promoter repeats. (A-iii) DNA amplification was confirmed by three TR₄₆³ strains (BE1-1, W1-4, W2-12-1), which have triple 46 bp promoter repeats. (B-i) DNA amplification was not confirmed by two TR₃₄² strains (IFM64460, IFM64733), which have duplicate 34 bp promoter repeats with one mutation in the one coding region (L98H). The dotted line shows amplification by the control strain. (B-ii) DNA amplification was not confirmed by one TR₃₄² strain (3-1-B), which has duplicate 34 bp promoter repeats with multi-mutations in the four coding regions (L98H/T289A/I364V/G448S). The dotted line shows amplification by the control strain.