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. 2021 Aug 24;11:17081. doi: 10.1038/s41598-021-96590-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic CYP2C9 activity (tolbutamide 4′-hydroxylation) (A) and CYP2C9 expression (B) in subjects carrying various CYP2C9 genotypes. CYP2C8*3 carriers and non-genetic factors (CYP2C9 inducer and inhibitor therapy, amoxicillin + clavulanic acid treatment, chronic alcohol consumption) found in clinical reports of the tissue donors are indicated. The median CYP2C9 activity (dotted line) is for the cutoff value between high and low intermediate metabolizers. PM poor metabolizer, IM intermediate metabolizer, EM extensive metabolizer, low low expression, intermediate intermediate expression, high high expression. *P < 0.05; **P < 0.001.