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. 2021 Aug 24;11:17136. doi: 10.1038/s41598-021-96618-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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iTRAQ proteomic analysis of biventricular response to volume overload due to ACF. (a, b) Vulcan plot of identified proteins in RV and LV. X axis represents log2 of fold change compared to controls, Y axis -log10 of p-value. (c) Venn diagrams of differentially regulated proteins in ACF compared to controls (significant difference with threshold > 1.5-fold). (d) ACF-induced changes (log2 of fold-) in RV (X axis) vs LV (Y axis). Note departure of the regression line (with 95% CI, red) from identity line (dashed), towards RV. The proteins with relatively highest differential regulation in RV are labeled in red. For abbreviations, see text.