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. 2021 Aug 24;6:107. doi: 10.1038/s41541-021-00365-w

Fig. 4. mCuMVTT-MERS vaccine induces RBD and spike-specific IgG subclasses as well as isotype switching to IgA.

Fig. 4

a RBD-specific IgG1, IgG2a, IgG2b and IgG3 titers for the groups vaccinated with CuMVTT control or mCuMVTT-MERS measured with OD450. b Log10 OD50 values (mean ± SEM) of RBD-specific IgG1, IgG2a, IgG2b and IgG3 titer for the groups vaccinated with mCuMVTT-MERS, (p value 0.0202 for IgG1 vs IgG2b, p value 0.0096 for IgG1 vs IgG3). Statistical analysis using One-way ANOVA. Control group n = 4 and vaccine group n = 4. c RBD-specific IgA titer for the groups vaccinated with CuMVTT control or mCuMVTT-MERS measured with OD450. d Log10 OD50 values (mean ± SEM) of RBD-specific IgA titer for both groups, (p value < 0.0001). Statistical analysis using Student’s t test. Control group n = 5 and vaccine group n = 5. One representative of two similar experiments is shown. The value of p < 0.05 was considered statistically significant (*p < 0.01, **p < 0.001, ***p < 0.0001).