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. 2021 Aug 24;12:5086. doi: 10.1038/s41467-021-25177-3

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Project schematic, showing a human image to represent multiple patients with different cancer diagnoses (pan-cancer). Tumor samples, implanted in mice to form PDX models, are propagated through a sequence of hosts, some of which provide specimens for next-generation sequencing and genomic analysis. b Sample types (left) and sequence data by assay (top) and associated counts of human cases and PDX models (right). c Distributions of cases according to the number of PDX passage indices (upper left) and PDX samples (upper right) in the lineage. Analogous distributions for PDX models (lower set) are also shown. d Distribution of cases by cancer type, following TCGA study abbreviations where possible. e Clinical features of cases (age at diagnosis, gender, self-reported race) and specimens (tumor status, treatment status), and PDTC source of sequence data. Key: PDTC, PDX Development and Trial Center; PDX, patient-derived xenograft; RNA-seq, RNA sequencing; TCGA, The Cancer Genome Atlas; WES, whole exome sequencing. Cancer type definitions in this work: BLCA, Bladder/urothelial carcinoma; BRCA, breast carcinoma; CESC, cervical carcinoma; COAD, colon adenocarcinoma; CSCC, cutaneous squamous cell carcinoma; GBM, glioblastoma multiforme; GIAD, gastrointestinal carcinoma, NOS; GIST, gastrointestinal stromal tumor; HNSC, head-and-neck squamous cell carcinoma; KIRC, kidney renal clear cell carcinoma; LUAD, lung adenocarcinoma; LUAS, lung adenosquamous carcinoma; LUSC, lung squamous cell carcinoma; MCC, Merkel cell tumor; MESO, mesothelioma; OV, ovarian carcinoma (epithelial or NOS); PAAD, pancreatic adenocarcinoma; PRAD, prostate carcinoma, NOS; READ, rectal adenocarcinoma; SARC, sarcoma; SCLC, small cell lung carcinoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma. Source data are provided as a Source Data file.