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. 2021 Aug 24;12:5086. doi: 10.1038/s41467-021-25177-3

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–c Cis and trans effect of driver mutations on RNA expression from TCGA tumors and PDXs on three different cancer types: bladder (BLCA), colorectal (COADREAD), and skin cutaneous melanoma (SKCM). Boxplots for the cis effect (d) and trans effect (e, f) of key driver genes on gene expression. Number of samples (n) for each group is shown in the figure. The box boundary of each box plot indicates third quartile and first quartile respectively from the top to bottom. The whisker on top were drawn out from the third quartile to the largest data point or up to 1.5 × IQR. Similarly, the bottom whisker extends from the first quartile down to 1.5 × IQR or the lowest data point. The red dot at the center indicates medium. Source data are provided as a Source Data file.