Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 24;12:5086. doi: 10.1038/s41467-021-25177-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Top panel is four major pan-cancer transcriptional groups (limegreen, skyblue, oceanblue, and light olive) identified from the expression of significant positive differentially expressed genes (FDR > 0.05, fold change > 1) of each transcriptional group in cancer types with sample size greater than 20. Those include Bladder Urothelial Carcinoma (BLCA), Breast invasive carcinoma (BRCA), Colon adenocarcinoma (COAD), Head and Neck squamous cell carcinoma (HNSC), Kidney renal clear cell carcinoma (KIRC), Lung adenocarcinoma (LUAD), Lung squamous cell carcinoma (LUSC), Pancreatic adenocarcinoma (PAAD), Rectum adenocarcinoma (READ), Sarcoma (SARC), Small cell lung cancer (SCLC), Skin Cutaneous Melanoma (SKCM), Uterine Carcinosarcoma (UCS). The heatmap shows differentially expressed genes (DEGs) from each group. Bottom panel is the ratio of each cancer type in each transcriptional group. b Dimension reduction UMAP 2D-plots using 1000 most variable genes. Each point represents one sample. Colors in each panel indicate respectively cancer type, transcriptional group, system, cluster shift score, passage, and sample type of each sample. c Normalized medium expression of genes in major oncogenic pathways. d First panel is the distribution of cluster shift score. Second and third panel are the pedigree tree and the 2D distribution of case PMDR-521955. Each color (light coral, yellow green, purple, and light teal) indicates one PDX model originated from the same hurman tumor sample. In the second panel, filled circles are human samples with RNA-Seq data. Hollow circle and dot are human and PDX sample without data. Fourth panel is an example of PDX models without cluster shift. Each color (red, blue, and green) indicates samples from one PDX model. Source data are provided as a Source Data file.