Table 2.
Structural, functional and stability analysis of the SLC6A4 protein.
| SNP ID | Variant | MUpro |
I-Mutant |
MutPred |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Prediction SVM | Score | Prediction NN | Score | Prediction | RI | DDG | P Value | ||
| rs200953188 | R104C | Decrease | -0.886 | Decrease | -0.546 | Decrease | 7 | -1.48 | 0.942 |
| rs758510581 | Y121C | Decrease | -0.900 | Decrease | -0.568 | Decrease | 2 | 0.43 | 0.95 |
| rs772080063 | W82R | Decrease | -1.054 | Decrease | -0.559 | Decrease | 7 | -1.69 | 0.95 |
| rs1221448303 | R79W | Decrease | -0.398 | Decrease | -0.600 | Decrease | 7 | -0.19 | 0.87 |
| rs774597104 | W151R | Decrease | -1.877 | Decrease | -0.914 | Decrease | 9 | -1.53 | 0.957 |