REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-LAMP2	ThermoFisher Scientific	Cat# PA1-655; RRID: AB_2134625
Anti-COX IV	Abcam	Cat# ab16056; RRID: AB_443304
Anti-Phospholamban	Abcam	Cat# ab85146; RRID: AB_10974942
PO448 Polyclonal Goat Anti-Rabbit Immunoglobulins/HRP	Agilent Dako	Cat# P044801-2; RRID: AB_2617138
Chemicals, peptides, and recombinant proteins
Westar Supernova detection substrate	Cyanogen	XLS3,0020
Bolt™ 4 to 12%, Bis-Tris, 1.0 mm, Mini Protein Gel, 10-well	ThermoFisher Scientific	NW04120BOX
Lysosome Isolation Buffer	BioVision	K235-50-1
Lysosome Enrichment Buffer	BioVision	K235-50-2
Protease Inhibitor Cocktail	BioVision	K235-50-4
Sucrose	Fisher Scientific	15503022
Percoll	Santa Cruz Biotechnology	sc-500790
4-Methylumbelliferyl N-acetyl-β-D-glucosaminide	Merck (Sigma-Aldrich)	CAS 37067-30-4
Sodium Acetate Buffer	Merck (Sigma-Aldrich)	CAS 126-96-5
Triton X-100 solution	Merck (Sigma-Aldrich)	CAS 9002-93-1
Na2CO3	Merck (Sigma-Aldrich)	CAS 497-19-8
Dithiothreitol	Merck (Sigma-Aldrich)	CAS 3483-12-3
Iodoacetamide	Merck (Sigma-Aldrich)	CAS 144-48-9
Urea	Merck (Sigma-Aldrich)	CAS 57-13-6
TRIS HCL	Merck (Sigma-Aldrich)	CAS 1185-53-1
Deposited data
Mass spectrometry proteomics data, Proteome Xchange via PRIDE partner repository, dataset identifier PRIDE: PXD021277	This paper	http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021277
Proteomic map of the human heart	Doll et al. 2017	https://www.nature.com/articles/s41467-017-01747-2#additional-information
Experimental models: Organisms/strains
Dunkin Hartley Guinea Pig (Male) HsdDhl:DH	Envigo	Order code: 459
Software and algorithms
MaxQuant software platform (version 1.6.2.3)	Cox and Mann 2008	https://www.maxquant.org
Perseus software platform (version 1.5.2.4)	Tyanova et al. 2016	http://coxdocs.org/doku.php?id=perseus:start
Prism v8	GraphPad	https://www.graphpad.com
UniProt Retrieve/ID Mapping	Uniprot KB	https://www.uniprot.org/uploadlists/
Cytoscape (Version 3.7.2)	Shannon et al. 2003	https://cytoscape.org
ClusterMaker v2.8.2	Morris et al. 2011	http://www.cgl.ucsf.edu/cytoscape/cluster/clusterMaker.shtml
Panther Gene Ontology Pathway Analysis Software	Mi et al., 2021	http://pantherdb.org
Other
Thermo Scientific™ EASY-Spray™ HPLC Columns	ThermoFisher Scientific	ES803
PepMAP C18, 75 μm x 500mm, 2 μm particle HPLC column	ThermoFisher Scientific	164942
Sola HRP SPE cartridges	ThermoFisher Scientific	60109-001