Table 2.

Insulin dose adjustment according to presence of pre-meal blood glucose tests and meals

Test/meal conditions according to treatment groups	Morning	Mid-day	Evening
Group 70a
BG test done, meal taken	Planned doseb	≤ 240 mg/dL: no insulin  > 240 mg/dL: 2 ×  ICD	Planned dose
No BG test, meal taken	Planned dose	No insulin	Planned dose
BG test done, no meal	< 80 mg/dL: no insulin  ≥ 80 mg/dL: 3 ×  ICD	≤ 240 mg/dL: no insulin  > 240 mg/dL: 2 ×  ICD	< 80 mg/dL: no insulin  ≥ 80 mg/dL: 1 × ICD
No BG test, no meal	3 × ICD value of 151–180 mg/dL sliding scale range	No insulin	No insulin
Group NRa
BG test done, meal taken	N: Planned dose R: MID	N: ∅ R: ∅ for ≤ 240 mg/dL ICD for > 240 mg/dL	N: Planned dose R: MID + ICD
No BG test, meal taken	N: Planned dose R: MID	N: ∅ R: ∅	N: Planned dose R: MID
BG test done, no meal	N: 1/3 or 1/2 planned dose R: ICD	N: ∅ R: ∅ for ≤ 240 mg/dL ICD for > 240 mg/dL	N: ∅ R: ICD
No BG test, no meal	N: 1/3 or 1/2 planned dose R: ∅	N: ∅ R: ∅	N: ∅ R: ∅

BG Blood glucose, MID meal insulin dose

^aGroup 70 (G70) were treated with the 70/30 insulin formulation; Group NR (GNR) switched to self-mixed Neutral Protamine Hagedorn (NPH) +  regular (R ) insulin

^bPlanned dose is defined as the previous dose adjusted, when needed, to have its effect on BG

∅: no insulin