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. 2021 Aug 24;4:1001. doi: 10.1038/s42003-021-02526-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Brightfield microscope images of SW620 tumour spheroids at day 0 and 7 days following different treatment schedules with SN38 and AZD0156: A Untreated day 0; B SN38 monotherapy; C SN38 + AZD0156 1/7; D SN38 + AZD0156 7/7; E SN38 + AZD0156 3/7 (24 h gap); F SN38 + AZD0156 3/7 (72 h gap); G Untreated day 7; b Spheroids were imaged in situ in the chip at day 7 and their volumes calculated from average radius deducted from min/max Feret. c Spheroids were recovered from the chip at day 7 and their viability measured by CellTiterGlo assay. n ≥ 5 per condition from two independent experiments. Box-plots show median (centre line); box limits are 25th to 75th percentile; whiskers represent min and max values. Statistical analysis using 1-way ANOVA, Tukey’s multiple comparisons, CI = 95%, ****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.1.