Table 1.

List of the 16 proteins that show decreased secretion by MMP2 KD in CRC cells and increased levels in the plasmas of CRC patients during disease progression from stage I to II.

Accession No	Protein name	Gene name	Plasma (LFQ)				Secretome (SILAC)
			Z-score				Log2 (MMP2-KD/ control)	p-value
			CRC I	CRC II	CRC III	CRC IV
P05556	Integrin beta-1	ITGB1	− 0.77	1.46	− 0.54	− 0.15	− 0.97	0.005
P21926	CD9 antigen	CD9	− 0.81	1.26	− 0.82	0.37	− 0.70	0.016
Q86SQ4	G-protein coupled receptor 126	GPR126	− 0.72	1.49	− 0.36	− 0.41	− 1.02	0.03
P20827	Ephrin-A1	EFNA1	− 1.06	1.27	− 0.47	0.27	− 1.00	0.016
Q15828	Cystatin-M	CST6	− 1.02	1.36	− 0.37	0.03	− 0.97	0.045
P30530	Tyrosine-protein kinase receptor UFO	AXL	− 1.38	1.02	0.3	0.07	− 0.89	0.039
P22455	Fibroblast growth factor receptor 4	FGFR4	− 0.61	1.46	− 0.7	− 0.17	− 0.80	0.033
P43121	Cell surface glycoprotein MUC18	MCAM	− 0.6	1.48	− 0.66	− 0.23	− 0.76	0.005
Q14118	Dystroglycan	DAG1	− 0.45	1.5	− 0.4	− 0.66	− 0.66	0.043
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	HSPG2	− 1.03	1.3	0.22	− 0.49	− 0.64	0.049
P10316	HLA class I histocompatibility antigen	HLA-A	− 1.21	1.16	− 0.32	0.37	− 0.74	0.052
P01034	Cystatin-C	CST3	− 1.37	0.92	− 0.1	0.55	− 0.72	0.06
P39060	Collagen alpha-1(XVIII) chain;Endostatin	COL18A1	− 0.94	1.41	− 0.4	− 0.08	− 0.74	0.064
O00592	Podocalyxin	PODXL	− 1.33	1.1	− 0.03	0.26	− 0.62	0.09
P10909	Clusterin	CLU	− 1.4	0.99	0.24	0.19	− 0.85	0.092
Q99715	Collagen alpha-1(XII) chain	COL12A1	− 1.25	1.18	0.21	− 0.14	− 0.60	0.122