Fig. 2. Overview of the patient´s clinical features.

A Applying published criteria [5, 6], 51/160 patients were classified as being positive for at least one clinical criteria indicating a cancer predisposition. B This plot depicts how often a clinical criteria co-occurs with another clinical criteria in a given patient. The co-occurrence is indicated by the numbers in the circles, the smallest circles without a number represent single cases. Of note, the patients with excessive toxicity always harbor in addition another clinical sign. Hence, there are no patients who just harbor solely excessive toxicity as a single clinical sign (indicated by a “-ˮ). A suspicious tumor diagnosis occurred in 14 patients as the sole clinical sign whereas congenital anomalies often co-occur with a positive family anamnesis or a suspicious tumor diagnosis.