Table 2.
Summary of GPCRs functions and result in the chemotaxis assays. Information on expression profile and function of each receptor was acquired from WormBase version WS273. Comparison between N2 and mutant strains chemotaxis index is reported (p-value). *P < 0.05, ***P < 0.0001, ns = non significant.
| Gene name | Neuron | Functions | p-value |
|---|---|---|---|
| sra-13 | AWA-AWC | It exhibits olfactory receptor activity. Found to mediate negative regulation of RAS/MAPK cascade during olfaction of volatile attractants47 | 0.0001 (***) |
| str-2 | AWCON | It exhibits olfactory receptor activity. Required for attraction towards 2-heptanone9 | 0.03 (*) |
| odr-10 | AWA | It exhibits olfactory receptor activity and binds the odorant diacetyl. As yet, this is the only GPCR inC. elegans whose specific ligand has been determined48 | ns |
| sra-17 | AWA | It is predicted to have G protein-coupled receptor activity | 0.04 (*) |
| str-130 | AWCOFF | It is predicted to encode a protein with the following domain: 7TM GPCR, serpentine receptor class r (Str) | ns |
| str-199 | AWC | It is predicted to encode a protein with the following domain: 7TM GPCR, serpentine receptor class r (Str) | ns |
| srsx-5 | AWC | It is predicted to have G-protein coupled receptor activity | ns |
| sri-14 | AWC | It is required for detection of chemical stimulus. It senses the odorant diacetyl at high concentration in ASH neurons fostering avoidance responses25 | Not tested (motility defects) |
| srt-26 | AWC | Pseudogene. Expression was detected in the intestine and the nervous system | Not tested (pseudogene) |