Fig. 4. Brian reactivity to smoking-related cues at baseline (day 1).

A Brain regions that showed a significant increase in activation in response to smoking-related cues at baseline (smoking-related cues > neutral cues). The peak brain regions were the caudate and postcentral gyrus. B A positive correlation was found between the increase in postcentral gyrus activity and the severity of nicotine dependence, measured by FNDT scores. C Reaction time during the cue-reactivity paradigm, with a main effect of cue type (i.e., the reaction time for smoking-related cues was longer than for neutral cues) and time (i.e., the reaction time on day 3 was shorter than on day 1).