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. 2021 Aug 24;8:222. doi: 10.1038/s41597-021-01007-5

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© The Author(s) 2021

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Fig. 1 — Schematic representation of the unbiased template creation procedure by Fonov et al. 2011. (a) the initial model (Model 0) is mapped to each subject. (b) Mapping of individual subjects to the next model (Model 1). (c) the new model is mapped to each subject. (d) Mapping of individual subjects to the next model (Model 2). (e) The process is iteratively repeated until the final model is generated.