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. 2021 Aug 24;11:17132. doi: 10.1038/s41598-021-96630-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of RV ECV and their association with CK-MB. (A): the change of ECV in the RV between the baseline MRI study and the final CMR (ΔECV) in each patient correlated with the change of CK-MB (ΔCK-MB) a serum biomarker of myocardial injury. (B) RV ECV increased approximately linearly with time from anthracycline therapy. The rate of RV ECV expansion over time after anthracycline therapy (P < 0.001 for follow-up-time coefficient estimate) increased in proportion to the serum level of CK-MB activity (P < 0.001 for interaction of follow-up time with log-transformed CK-MB level). The longitudinal change of RV ECV was modeled with a linear mixed effects model that included follow-up time (days), log-transformed CK-MB and an interaction term as predictors. The blue and red lines show the predictions from this model for two levels of CK-MB corresponding to the overall mean (blue) of CK-MB and a one standard deviation higher level (red), respectively.