Figure 2.

An example of co-locating T2D and eQTL locations, or ‘T2D-eQTL’ (chr13). Plotted is physical distance (kb coordinate) against genetic distance in linkage disequilibrium units (LDU), based on a European genetic map constructed by Lau et al. (3). The blue line shows cumulative LDU across the region in a ‘step’ and ‘block’ structure, corresponding to regions of LD breakdown and extended LD, respectively. Blue and red arrows correspond to Ŝ_T2D location estimates associated with T2D in the Wellcome Trust European and African American populations (WTC and AA), respectively, with horizontal arrows illustrating the asymmetrical physical distance extending ±1 LDU. The dotted arrows show Ŝ_eQTL location estimates for two cis-genes, PCCA which is a nuclear-encoded mitochondrial gene (NEMG) and TMTC4, which is not (confidence intervals not shown). All Ŝ_T2D and Ŝ_eQTL location estimates are provided in Table 1.