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PLS-DA score plots and disturbed metabolic pathways across groups. (a) PLS-DA score plot across HIV– NCs, HIV+ NCs and HIV+ NCDs. The disturbed metabolic pathways showed various metabolism changes when comparing (b) HIV– NCs across age groups; (c) HIV– NCs across age groups; (d) HIV+ NCs vs HIV– NCs; (e) HIV+ SCA vs HIV+ NCs; (f) HIV+ LF vs HIV+ NCs; (g) HIV+ NCI vs HIV+ NCs; (h) HIV+ RI vs HIV+ NCs. Y indicates age range of 18–29 years; M indicates 30–44 years; O indicates 45–65 years.
