Spearman correlation matrix between eigenmetabolite, altered metabolites, classical lipids, and clinical parameters in all participants. Shades of blue indicate increasing positive correlation coefficient; shades of red indicate increasing negative correlation coefficient. Variables were ordered using hierarchical clustering analysis. The threshold after bonferroni correction for 1653 tests at *p < 0•00003025 (0•05/1,653), ⁎⁎p < 0•0000605 (0•01/1,653), and ⁎⁎⁎p < 0•000006 (0•001/1,653).