Fig. 4.

Estimated marginal mean scores over time for secondary PROMs: (A) DT (scores ranging from 0 to 10; high score indicates more distress); (B) 38-item PL (39 items, scores ranging from 0 to 38; high score indicates more distress); (C) BDI-II (21 items, scores are classified as minimal (0–13), mild (14-19), moderate (20-28), and severe (29-63)); (D) FACIT-Fatigue (13 items, scores ranging from 0 to 52; high score indicates less fatigue), separately for both treatment arms in the total study population, based on results of the linear mixed model analyses.

Results of the linear mixed model analyses indicated that the DT, 38-item PL, BDI-II and FACIT-fatigue scale significantly improved from T0 to T1 in the immediate treatment group (ITG) (p<0.001). This did not continue at T2 (p>0.05). In the wait-list control (WLC) group, the 38-item PL was already statistically significant improved from T0 to T1 (p<0.01) which continued at T2 (p<0.001). The DT, BDI-II and FACIT-fatigue scale only improved as from T1 in the WLC group (p<0.001).

Legend: blue = immediate treatment group; red = wait-list control group. Error bars present 95% confidence interval for estimated marginal mean.

Abbreviations: PROMs: patient-reported outcome measures; DT: distress thermometer; PL: 38-item problem list (PL); BDI-II: Beck Depression Inventory-II; FACIT-Fatigue: Functional Assessment of Chronic Illness Therapy-Fatigue Subscale (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).