Fig. 5.

Estimated marginal mean scores over time for HRQoL measures, derived from the EORTC QLQ-C30: (A) Summary Score; (B) Global Health Status; (C) Emotional functioning; (D) Cognitive functioning; (E) Social functioning; (F) Fatigue, separately for both treatment arms in the total study population, based on results of the linear mixed model analyses. All of the scales range in score from 0 to 100.

Results of the linear mixed model analyses indicated that the Summary Score, Global Health Status, Emotional functioning, Cognitive functioning, Social functioning and Fatigue significantly improved from T0 to T1 in the immediate treatment group (ITG) (p<0.001). This did not continue at T2 (p>0.05). For the wait-list control (WLC) group, there was no significant improvement observed at T1 (p>0.05). Improvement in the WLC for Summary Score (p<0.001), Global Health Status (p<0.001), Emotional functioning (p<0.001) Cognitive functioning (p<0.001), Social functioning (p<0.05) and Fatigue (p = 0.001) was observed at T2.

Legend: blue = immediate treatment group; red = wait-list control group. Error bars present 95% confidence interval for estimated marginal mean.

Abbreviations: HRQoL: health-related quality of life; EORTC QLQ-C30: European Organization for Research and Treatment for Cancer QoL Questionnaire (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).