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. 2021 Aug 10;46:102098. doi: 10.1016/j.redox.2021.102098

Fig. 3.

Fig. 3

Pae attenuated diabetes-induced cardiac functional abnormalities in rats. Control non-diabetic or diabetic rats were treated with Pae for 12 weeks and their cardiac function was analyzed. (a) Representative echocardiography images. (b-e) Quantitative analysis of echocardiography data including left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular end-systolic diameter (LVESD) and Left ventricular end-diastolic diameter (LVEDD). (f-g) Representative pulse-wave Doppler images and quantitative analysis of the E/A ratio. DM, diabetes mellitus; Pae (75, 150, 300), paeonol at a dosage of 75, 150 or 300 mg/kg/day respectively; n = 8 in each group. (h-k) Quantitative analysis of hemodynamic data including LV systolic pressure (LVSP), LV end-diastolic pressure (LVEDP) and the maximal and minimal first derivative of LV pressure (±LV dP/dtmax). Pae, paeonol at a dosage of 300 mg/kg/day; n = 6 in each group. All data are shown as means ± SEM. *P < 0.05, **P < 0.01.