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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Environ Int. 2021 Jul 19;156:106772. doi: 10.1016/j.envint.2021.106772

Table 3:

Statistically significant DMSs (FDR < 0.05) associated with PBDE serum levels in samples from 313 healthy controls.

Cpg IDa Chr Location Gene Gene region P-value FDR Effect sizeb Association Analysisc
cg17748822 1 40234041 BMP8B Body 1.77E-08 0.014 −0.005 BDE-153 Primary
cg16663424 1 54562396 TCEANC2 3’UTR 2.75E-08 0.021 0.042 BDE-153 Secondary
cg09347135 2 71890349 DYSF Body 9.41E-08 0.024 −0.046 BDE-153 Secondary
cg21115527 7 75931838 HSPB1 TSS200 7.08E-08 0.024 0.005 BDE-153 Secondary
cg00856432 3 53755477 CACNA1D Body 2.14E-07 0.028 0.042 BDE-153 Secondary
cg06113552 1 54562389 TCEANC2 3’UTR 1.48E-07 0.028 0.060 BDE-153 Secondary
cg16646600 1 54562543 C1orf83 3’UTR 1.83E-07 0.028 0.049 BDE-153 Secondary
cg09785344 15 101389974 5.86E-08 0.036 0.006 BDE-47 Primary
cg15646096 1 155160365 MUC1 Body 9.19E-08 0.036 −0.008 BDE-47 Primary
cg05371417 4 139113574 SLC7A11 Body 1.85E-07 0.036 −0.007 BDE-153 Primary
cg07103072 20 32951050 ITCH TSS200 1.82E-07 0.036 0.001 BDE-153 Primary
cg23416540 15 45571777 SLC28A2-AS1 TSS1500 1.40E-07 0.036 0.005 BDE-153 Primary
cg10826200 19 4247502 CCDC94 Body 2.46E-07 0.038 0.003 BDE-153 Primary
cg22117172 7 91764530 CYP51A1 TSS1500 3.39E-07 0.044 0.007 BDE-153 Primary
cg16115867 17 46755566 4.07E-07 0.045 −0.009 BDE-153 Primary
a

CpG IDs with bold font were selected for validation by next generation bisulfite sequencing

b

effect size is on the scale of M values in the linear regression model; in the primary analysis, the effect size is M value changes per 1 unit of log2(BDE) increase (per doubling of PBDE concentration); in the secondary analysis, the effect size is the mean M value difference between two sample groups determined by the 25% and 75% BDE percentiles

c

In the linear regression model, M value methylation = BDE + covariates, BDE was either a continuous predictor variable log2(BDE) in the primary analysis or a categorical variable (two sample groups determined by 25% and 75% BDE percentiles) in the secondary analysis.