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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Environ Int. 2021 Jul 19;156:106772. doi: 10.1016/j.envint.2021.106772

Table 4.

Statistically significant DMRs (FDR < 0.05) associated with PBDE serum levels in samples from 313 healthy controls.

Associationa Chrb DMR start DMR end CpGc Nearby gene Gene region Peak Pd FDRe Meanf diff
BDE-153 12 9217079 9217907 10 A2M-AS1 TSS200 8×10−6 0.0002 0.0109
BDE-153 15 45669010 45671347 19 GATM TSS1500 1×10−3 0.0379 −0.0029
BDE-153 10 134777785 134779406 8 LINC01168 TSS1500 3×10−6 0.0056 −0.0090
BDE-100 10 134777785 134779406 8 LINC01168 TSS1500 1×10−4 0.0214 −0.0081
BDE-47 10 134777785 134778648 6 LINC01166 TSS1500 3×10−3 0.0213 0.0067
BDE-100 10 134150119 134151130 12 LRRC27 TSS200 6×10−6 0.0049 −0.0378
BDE-47 10 134150119 134151130 12 LRRC27 TSS200 2×10−5 0.0030 −0.0388
BDE-153 10 134150119 134151130 12 LRRC27 TSS200 3×10−3 0.0164 −0.0252
BDE-153 22 18463400 18463646 4 MICAL3 5’UTR 1×10−5 0.0224 −0.0094
BDE-100 12 124873347 124874007 5 NCOR2 TSS1500 7×10−4 0.0056 0.0299
BDE-153 1 163037784 163039184 16 RGS4 5’UTR 2×10−5 0.0399 −0.0172
BDE-153 1 3585225 3585587 5 TP73 TSS1500 2×10−3 0.0051 −0.0181
BDE-100 10 5406143 5407594 13 UCN3 TSS200 2×10−4 0.0178 −0.0113
BDE-153 10 5406143 5407594 12 UCN3 TSS200 4×10−4 0.0140 −0.0029
a

Association between a BDE level and multiple CpG sites in a region tested by DMRcate method

b

Chromosome position is based on GRCh37/(hg19)

c

Number of CpG sites in a DMR(differentially methylated region)

d

smallest p-value among multiple CpG sites in a region associated with BDE exposure from identification of individual differentially methylation site

e

overall regional significance of a DMR, Benjamini-Hochberg adjusted for the total number of tested regions agglomerated from groups of individual significant CpG sites

f

Mean methylation changes across all CpG sites in a region in relation to one unit of log2(BDE) in the primary analysis or mean methylation difference between samples with top and bottom 25% BDE concentration in the secondary analysis(italic font).