Table 1.
Characteristics of enrolled patients with sepsis included in the derivation group and validation group.
| Derivation group | Validation group | P-value | |
|---|---|---|---|
| N | 59 | 55 | |
| Male (%) | 33 (55.9%) | 31 (56.4%) | 0.696 |
| Age (yr) | 71.0 (61.0, 78.0) | 75.0 (64.0, 84.7) | 0.067 |
| Laboratory data | |||
| Mean arterial pressure (mm Hg) | 79.3 (71.5, 90.2) | 77.6 (68.7, 90.0) | 0.610 |
| White blood cell count (109/L) | 12.8 (7.6, 18.4) | 12.4 (7.4, 18.4) | 0.933 |
| Haemoglobin (g/l) | 114.5 (92.7, 127.0) | 107.0 (83.0, 129.5) | 0.432 |
| Haematocrit (%) | 33.9 (28.3, 38.3) | 32.3 (26.3, 39.3) | 0.570 |
| Platelet count (109/L) | 136.0 (68.3, 198.7) | 133.0 (73.5, 174.0) | 0.917 |
| Albumin (g/dl) | 27.2 (25.0, 29.95) | 27.0 (24.4, 30.8) | 0.041 |
| Aspartate aminotransferase (U/l) | 46.0 (26.5, 127.5) | 40.0 (24.0, 82.0) | 0.614 |
| Alanine aminotransferase (U/l) | 30.0 (18.0, 68.0) | 21.0 (14.0, 42.0) | 0.144 |
| Total bilirubin (μmol/l) | 15.8 (8.0, 26.1) | 15.9 (10.9, 44.2) | 0.414 |
| Creatinine (μmol/l) | 135.0 (95.0, 218.0) | 103.0 (73.5, 199.5) | 0.078 |
| INR | 1.2 (1.1, 1.3) | 1.3 (1.1, 1.4) | 0.818 |
| Infection | 0.832 | ||
| Gram-positive bacteria (%) | 7 (11.9%) | 3 (5.5%) | |
| Gram-negative bacteria (%) | 24 (40.7%) | 23 (41.8%) | |
| Viral (%) | 1 (1.7%) | 1 (1.8%) | |
| Other (%) | 27 (45.7%) | 28 (50.9%) | |
| CRRT | 8 (13.6%) | 7 (12.7%) | 0.246 |
| Vasopressors | 0.250 | ||
| No (%) | 32 (54.2%) | 33 (60.0%) | |
| Yes (%) | 25 (42.4%) | 22 (40.0%) | |
| Unknown (%) | 2 (3.4%) | 0 (0.0%) | |
| Mechanical ventilation | 0.555 | ||
| No (%) | 34 (57.6%) | 29 (52.7%) | |
| Yes (%) | 22 (37.3%) | 25 (45.5%) | |
| Unknown (%) | 3 (5.1%) | 1 (1.8%) | |
| Severity at time of intensive care unit admission | |||
| SOFA | 6.0 (4.0, 8.7) | 6.0 (4.0, 8.0) | 0.972 |
| APACHE II | 18.0 (11.0, 22.0) | 18.0 (13.0, 23.0) | 0.293 |
| Mortality | |||
| 28-d | 8 (13.6%) | 10 (18.2%) | 0.7 |
| 90-d | 8 (13.6%) | 11 (20.0%) | 0.39 |
Data are expressed as the mean ± SD, median (IQR) or number of patients (percentages). Continuous variables were compared by using t test and the Mann-Whitney U test, and categorical variables were compared by using the χ2 or Fisher’s exact test between the discovery and validation groups. SOFA, Sequential Organ Failure Assessment on day of sampling. APACHE II, Acute Physiology and Chronic Health Evaluation II. CRRT, Continuous Renal Replacement Therapy.