TABLE 2.
Magnesium promotes the regeneration of the peripheral nerve.
| Materials | Application | Degradability | Biocompatibility | Regeneration mechanism | Future researchimprovement | |
| Magnesium filaments | Mg | promote nerve regeneration | Yes | Yes | (1) contact guidance | increase the number of animals |
| (2) the release of ion may be ineffective | ||||||
| Mg | (1) promote nerve regeneration in short gaps | − | Yes | (1) axon nerve regeneration | overcome the problem of a critical gap size | |
| (2) cannot promote nerve regeneration in long gaps | (2) formation of normal blood vessel | |||||
| Mg, Al, Zn | promote nerve regeneration | − | Yes | (1) promote myelination | explore the degradation of magnesium | |
| (2) inhibit the inflammation | ||||||
| Magnesium alloy | Mg-10Li | nerve regeneration potential | ZN20 < NZ20 < Mg-10Li | Yes | Mg-10Li and ZN20 make axon dense and long | (1) reduce cytotoxicity caused by Mg2+ |
| ZN20 | Yes | (2) adjust the released amount of other ions | ||||
| NZ20 | No(cytotoxicity) | |||||
| Mg-based metallic glasses | Mg-Zn-Ca metallic glass system | nerve regeneration potential | Yes | Yes | control the corrosion | carry out in vivo experiment |
| Magnesium with surface coating | PEDOT on Mg | (1) nerve regeneration potential | Yes | − | control the corrosion | (1) co-deposition of other coatings |
| (2) good adhesion strength of PEDOT | (2) carry out in vivo experiment | |||||
| PEDOT/GO on Mg | (1) nerve regeneration potential | Yes | Yes | (1) control the corrosion | (1) involve the release of anti-inflammatory drugs | |
| (2) build-up of negative charges | (2) promote the attachment and neurite extension of primary neuron | (2) provide loci for surfaces functionalization | ||||
| TA/PVPON on Mg70Zn26Ca4 | (1) nerve regeneration potential | Yes | Yes | (1) control the corrosion | determine the concentration of other ions and their effects on nerve cell | |
| (2) self-healing ability | (2) promote the attachment of SCs | |||||
| HA on WE43 | a little nerve regeneration in vivo | Yes | Yes | control the corrosion | improve the flexibility of conduits | |
| Mg2+-improved biomaterials | PGSM-Mg | (1) promote SCs adhesion and proliferation in vitro | Yes | Yes | enhance the proliferation and neural-specific gene expression of SCs | (1) involve the release of drugs |
| (2) sustained release of Mg2+ | (2) favourable for procession | |||||
| PHBV with MgOl | (1) nerve regeneration potential | − | Yes | promote the growth of PC12 | (1) carry out in vivo experiment | |
| (2) easily processing | (2) favourable for procession | |||||
“−” means it did not be studied. NZ20: Mg-Sn-Zn; ZN20: Mg-2Zn-Nd; PEDOT: Poly (3,4-ethylenedioxythiophene); GO: graphene oxide; TA/PVPON: tannic acid/poly (N-vinylpyrrolidone); HA: hydroxyapatite; WE43: Mg, 3.78%Y,2.13%Nd,0.46% Zr; PGSM: poly(glycerol-sebacate-maleate); PHBV: poly (3-hyroxybutyric acid-co-3-hydroxyva-leric acid); MgOl: magnesium-oleate.