Figure 6.

FUTC-based functional testing guided treatment of a patient with refractory lung adenocarcinoma

(A) Treatment outline and measured CSE and NSA levels of a patient with EGFR mutant lung adenocarcinoma.

(B) A surgically removed tissue specimen was used for FUTC-based drug testing of 233 single drugs or drug combinations in duplicate.

(C) Correlation plot comparing the DSS from the 2 replicate tests.

(D) The drug sensitivity scores of the top 20 hits, with general toxicity based on activity on normal cells noted.

(E and F) Changes in the level of CEA and NSE (E) and (F) tumor size after carboplatin plus etoposide treatment.

(G) Representative images of hematoxylin and eosin (H&E) and IHC staining performed on surgically resected tumor tissue.