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. 2021 Sep;105:103158. doi: 10.1016/j.dnarep.2021.103158

Fig. 4.

Fig. 4

A sub-group of DNet-genes lower cancer prognosis by increasing mutational burden. (A) Association with tumour mutational burden (TMB) vs association with survival of all DNet-genes in all cancer sub-types with the 4 groups of cooperative change labelled groups 1-4. (B) Size comparison of the groups from (A) for DNet-genes against those for canonical DNA repair genes and randomly selected genes. (C) Comparison of group sizes from (A) split by ACC and all other cancer sub-types. (D) Protein interaction network (left) and gene ontology slim biological process enrichment (right) for all group 4 genes from (A) that are in adrenocortical carcinoma (ACC).