Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 11;12:698249. doi: 10.3389/fimmu.2021.698249

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Feng, Min, Liang, Chen, Chen, Zhou, Deng, Liu and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Mechanism of neutrophil extracellular traps (NETs) exacerbates secondary injury after spinal cord injury. Infiltrated neutrophils produce NETs, which subsequently promote neuroinflammation and blood–spinal cord barrier disruption to aggravate spinal cord edema and neuronal apoptosis partly via elevating transient receptor potential vanilloid type 4 (TRPV4) level following SCI in rats. Both inhibition of NETs formation by peptidylarginine deiminase 4 (PAD4) inhibitor and disruption of NETs by DNase 1 alleviate secondary damage and promote functional recovery after SCI.