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. 2021 Aug 11;12:698249. doi: 10.3389/fimmu.2021.698249

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Copyright © 2021 Feng, Min, Liang, Chen, Chen, Zhou, Deng, Liu and Hou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restricting NETs reduces both glial and fibrotic scar formation after SCI. (A) Representative images of GFAP (green) positive glial scar in injured spinal cord of each group at 28 days after operation. Nuclear was marked with DAPI (blue). (B) Representative images of Laminin (red) positive fibrotic scar in injured spinal cord of each group at 28 days after operation. Nuclear was marked with DAPI (blue). Scale bars = 100 μm. Fluorescence intensity mean value (IMV) of (C) GFAP and (D) Laminin at the injury epicenter of each group. Data are presented as means ± SD of n = 6 (*p < 0.05).